Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells
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چکیده
منابع مشابه
T cell receptor/CARMA1/NF-κB signaling controls T-helper (Th) 17 differentiation.
IL-17-producing CD4 T cells play a key role in immune responses against extracellular bacteria and autoimmunity. Nuclear factor κB (NF-κB) is required for T-cell activation and selected effector functions, but its role in Th17 differentiation is controversial. Using genetic mouse models that impede T-cell-NF-κB signaling either downstream of the T-cell receptor (TCR) or of IκB kinase β (IKKβ), ...
متن کاملModeling the Dynamics of T Helper 17 Induction and Differentiation
Background: CD4+ T cells play important roles in orchestrating immune responses, maintaining homeostasis and offering a functional control of immune responses. Depending on the cytokine milieu, a naïve CD4+ T cell differentiates into different phenotypes. The T helper 17 (Th17) phenotype remains controversial since it has been identified as an inductor of inflammation, but it contributes to the...
متن کاملthe roles of t helper 1, t helper 17 and regulatory t cells in the pathogenesis of sarcoidosis
sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. it is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. the balance between th1, th17 and regulatory t(treg) cells controls t-cell proliferation and activation.the th17/treg ratio in the peripheral blood and bronchoalveolar lavage fluid...
متن کاملGenes associated with T helper 17 cell differentiation and function.
Interleukin-17 (IL-17)-producing T helper cells (Th17 cells) constitute a lineage of CD4 effector T helper cells that is distinct from the Th1 and Th2 CD4 phenotypes. In humans, Th17 differentiation is induced in the presence of the cytokines IL-1 beta, IL-6 and TGF beta, whereas IL-23 maintains Th17 survival. Effector human Th17 cells express several cytokines and cell surface markers, includi...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2014
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1321245111